Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract<i> </i>of<i> Draceana reflexa</i> Leaves in Rats

Bassoueka D’Avila Judicaël; Okemi Andissa Nadege; Peneme Max Bonaventure Lazard; Lemba Nganga Ella; Abena Ange Antoine

doi:doi:10.11648/j.ajbio.20221006.14

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Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats

Bassoueka D’Avila Judicaël, Okemi Andissa Nadege, Peneme Max Bonaventure Lazard, Lemba Nganga Ella, Abena Ange Antoine

Published in American Journal of BioScience (Volume 10, Issue 6)

Received: 16 November 2022 Accepted: 5 December 2022 Published: 15 December 2022

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Abstract

Naturally, Anxiety is a public disorder of high co-morbidity related to epilepsy, an enduring neurologic disease considered by persistent seizures. Existing drugs used for these situations have some restrictions for example spiking side effects, deterioration, and ineptness in certain people needing the look for other possibilities. The aqueous extract of Draceana reflexa leaves is broadly used for its several health-promoting effects with release of seizures and anxiety in ethnomedicine. Medicinal plants used for the epilepsy therapy have been systematically revealed to own hopeful anticonvulsant and anxiolytic effects during the anticonvulsant activity in animal experiments and can be a basis of fresher antiepileptics. Then, Draceana reflexa as a plant which belongs to the Asparagaceae family has been used in traditional medicine in Congo Republic for treating epilepsy and anxiety. Therefore, the current research work aimed to assess anticonvulsant and anxiolytic effect of Draceana reflexa including its mechanism on severe and long-lasting administration when using rats. Extracts of Draceana reflexa leaves were investigated for anticonvulsant effect induced seizures in rats at doses of 50,100 and 200 mg/Kg, respectively. The results found indicated that the extract of Draceaena reflexa leaves at all doses increases and decreases significantly the time of onset and the duration of convulsions respectively. Draceaena reflexa aqueous extract shows also a significant decrease in motor activity as does Diazepam and an increase in the immobility time by using the forced swimming test. This study suggests that Draceaena reflexa leaves considering social interaction-promoting effect might be of profit as an accessory in refining the life superiority of epileptic patients.

Published in	American Journal of BioScience (Volume 10, Issue 6)
DOI	10.11648/j.ajbio.20221006.14
Page(s)	201-205
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Draceana reflexa, Extract, Anticonvulsant, Anxiolytic, Medicinal Plants

References

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[4]	MacKinney TG, Soti KR, Shrestha P, Basnyat B. 2015. Camphor: an herbal medicine causing 1020 grand mal seizures. BMJ Case Report. Available at: https://doi.org/10.1136/bcr-2014-1021 209101.
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[6]	Kamalraj R. 2011. Anticonvulsant Studies on Leaf Extract of Erythrina Indica Lam. International Journal of Pharmaceutical Sciences and Research 2 (10): 2729–2732.
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[14]	Radha, Manoj K, Sunil P, Ashok P, Sneh PB, Sushil C, Poonam C, Parameswari E, Ahmad A, Mahesh KS, Rahul D, Mohamed M. 2021. Evaluation of Nutritional, Phytochemical, and Mineral Composition of Selected Medicinal Plants for Therapeutic Uses from Cold Desert of Western Himalaya. Plants 10: 1-16.
[15]	Hina F, Muhammad S, Amer JMN. 2021. Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats. Dose-Response: An International Journal 2: 1-16.
[16]	Newton CR and Garcia HH. 2012. Epilepsy in poor regions of the world. The Lancet 380 (9848): 1193–1201, 2012.
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Bassoueka D’Avila Judicaël, Okemi Andissa Nadege, Peneme Max Bonaventure Lazard, Lemba Nganga Ella, Abena Ange Antoine. (2022). Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats. American Journal of BioScience, 10(6), 201-205. https://doi.org/10.11648/j.ajbio.20221006.14

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ACS Style

Bassoueka D’Avila Judicaël; Okemi Andissa Nadege; Peneme Max Bonaventure Lazard; Lemba Nganga Ella; Abena Ange Antoine. Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats. Am. J. BioScience 2022, 10(6), 201-205. doi: 10.11648/j.ajbio.20221006.14

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AMA Style

Bassoueka D’Avila Judicaël, Okemi Andissa Nadege, Peneme Max Bonaventure Lazard, Lemba Nganga Ella, Abena Ange Antoine. Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats. Am J BioScience. 2022;10(6):201-205. doi: 10.11648/j.ajbio.20221006.14

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@article{10.11648/j.ajbio.20221006.14,
  author = {Bassoueka D’Avila Judicaël and Okemi Andissa Nadege and Peneme Max Bonaventure Lazard and Lemba Nganga Ella and Abena Ange Antoine},
  title = {Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats},
  journal = {American Journal of BioScience},
  volume = {10},
  number = {6},
  pages = {201-205},
  doi = {10.11648/j.ajbio.20221006.14},
  url = {https://doi.org/10.11648/j.ajbio.20221006.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20221006.14},
  abstract = {Naturally, Anxiety is a public disorder of high co-morbidity related to epilepsy, an enduring neurologic disease considered by persistent seizures. Existing drugs used for these situations have some restrictions for example spiking side effects, deterioration, and ineptness in certain people needing the look for other possibilities. The aqueous extract of Draceana reflexa leaves is broadly used for its several health-promoting effects with release of seizures and anxiety in ethnomedicine. Medicinal plants used for the epilepsy therapy have been systematically revealed to own hopeful anticonvulsant and anxiolytic effects during the anticonvulsant activity in animal experiments and can be a basis of fresher antiepileptics. Then, Draceana reflexa as a plant which belongs to the Asparagaceae family has been used in traditional medicine in Congo Republic for treating epilepsy and anxiety. Therefore, the current research work aimed to assess anticonvulsant and anxiolytic effect of Draceana reflexa including its mechanism on severe and long-lasting administration when using rats. Extracts of Draceana reflexa leaves were investigated for anticonvulsant effect induced seizures in rats at doses of 50,100 and 200 mg/Kg, respectively. The results found indicated that the extract of Draceaena reflexa leaves at all doses increases and decreases significantly the time of onset and the duration of convulsions respectively. Draceaena reflexa aqueous extract shows also a significant decrease in motor activity as does Diazepam and an increase in the immobility time by using the forced swimming test. This study suggests that Draceaena reflexa leaves considering social interaction-promoting effect might be of profit as an accessory in refining the life superiority of epileptic patients.},
 year = {2022}
}

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TY  - JOUR
T1  - Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats
AU  - Bassoueka D’Avila Judicaël
AU  - Okemi Andissa Nadege
AU  - Peneme Max Bonaventure Lazard
AU  - Lemba Nganga Ella
AU  - Abena Ange Antoine
Y1  - 2022/12/15
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbio.20221006.14
DO  - 10.11648/j.ajbio.20221006.14
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 201
EP  - 205
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20221006.14
AB  - Naturally, Anxiety is a public disorder of high co-morbidity related to epilepsy, an enduring neurologic disease considered by persistent seizures. Existing drugs used for these situations have some restrictions for example spiking side effects, deterioration, and ineptness in certain people needing the look for other possibilities. The aqueous extract of Draceana reflexa leaves is broadly used for its several health-promoting effects with release of seizures and anxiety in ethnomedicine. Medicinal plants used for the epilepsy therapy have been systematically revealed to own hopeful anticonvulsant and anxiolytic effects during the anticonvulsant activity in animal experiments and can be a basis of fresher antiepileptics. Then, Draceana reflexa as a plant which belongs to the Asparagaceae family has been used in traditional medicine in Congo Republic for treating epilepsy and anxiety. Therefore, the current research work aimed to assess anticonvulsant and anxiolytic effect of Draceana reflexa including its mechanism on severe and long-lasting administration when using rats. Extracts of Draceana reflexa leaves were investigated for anticonvulsant effect induced seizures in rats at doses of 50,100 and 200 mg/Kg, respectively. The results found indicated that the extract of Draceaena reflexa leaves at all doses increases and decreases significantly the time of onset and the duration of convulsions respectively. Draceaena reflexa aqueous extract shows also a significant decrease in motor activity as does Diazepam and an increase in the immobility time by using the forced swimming test. This study suggests that Draceaena reflexa leaves considering social interaction-promoting effect might be of profit as an accessory in refining the life superiority of epileptic patients.
VL  - 10
IS  - 6
ER  -

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Author Information

Bassoueka D’Avila Judicaël
Okemi Andissa Nadege

Biochemistry and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo
Peneme Max Bonaventure Lazard

Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Techniques, Marien Ngouabi University, Brazzaville, Congo
Lemba Nganga Ella

Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Techniques, Marien Ngouabi University, Brazzaville, Congo
Abena Ange Antoine

Biochemistry and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo

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APA Style

Bassoueka D’Avila Judicaël, Okemi Andissa Nadege, Peneme Max Bonaventure Lazard, Lemba Nganga Ella, Abena Ange Antoine. (2022). Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats. American Journal of BioScience, 10(6), 201-205. https://doi.org/10.11648/j.ajbio.20221006.14

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ACS Style

Bassoueka D’Avila Judicaël; Okemi Andissa Nadege; Peneme Max Bonaventure Lazard; Lemba Nganga Ella; Abena Ange Antoine. Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats. Am. J. BioScience 2022, 10(6), 201-205. doi: 10.11648/j.ajbio.20221006.14

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AMA Style

Bassoueka D’Avila Judicaël, Okemi Andissa Nadege, Peneme Max Bonaventure Lazard, Lemba Nganga Ella, Abena Ange Antoine. Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats. Am J BioScience. 2022;10(6):201-205. doi: 10.11648/j.ajbio.20221006.14

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@article{10.11648/j.ajbio.20221006.14,
  author = {Bassoueka D’Avila Judicaël and Okemi Andissa Nadege and Peneme Max Bonaventure Lazard and Lemba Nganga Ella and Abena Ange Antoine},
  title = {Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats},
  journal = {American Journal of BioScience},
  volume = {10},
  number = {6},
  pages = {201-205},
  doi = {10.11648/j.ajbio.20221006.14},
  url = {https://doi.org/10.11648/j.ajbio.20221006.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20221006.14},
  abstract = {Naturally, Anxiety is a public disorder of high co-morbidity related to epilepsy, an enduring neurologic disease considered by persistent seizures. Existing drugs used for these situations have some restrictions for example spiking side effects, deterioration, and ineptness in certain people needing the look for other possibilities. The aqueous extract of Draceana reflexa leaves is broadly used for its several health-promoting effects with release of seizures and anxiety in ethnomedicine. Medicinal plants used for the epilepsy therapy have been systematically revealed to own hopeful anticonvulsant and anxiolytic effects during the anticonvulsant activity in animal experiments and can be a basis of fresher antiepileptics. Then, Draceana reflexa as a plant which belongs to the Asparagaceae family has been used in traditional medicine in Congo Republic for treating epilepsy and anxiety. Therefore, the current research work aimed to assess anticonvulsant and anxiolytic effect of Draceana reflexa including its mechanism on severe and long-lasting administration when using rats. Extracts of Draceana reflexa leaves were investigated for anticonvulsant effect induced seizures in rats at doses of 50,100 and 200 mg/Kg, respectively. The results found indicated that the extract of Draceaena reflexa leaves at all doses increases and decreases significantly the time of onset and the duration of convulsions respectively. Draceaena reflexa aqueous extract shows also a significant decrease in motor activity as does Diazepam and an increase in the immobility time by using the forced swimming test. This study suggests that Draceaena reflexa leaves considering social interaction-promoting effect might be of profit as an accessory in refining the life superiority of epileptic patients.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of Anticonvulsant and Anxiolytic Effects of Aqueous Extract of Draceana reflexa Leaves in Rats
AU  - Bassoueka D’Avila Judicaël
AU  - Okemi Andissa Nadege
AU  - Peneme Max Bonaventure Lazard
AU  - Lemba Nganga Ella
AU  - Abena Ange Antoine
Y1  - 2022/12/15
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbio.20221006.14
DO  - 10.11648/j.ajbio.20221006.14
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 201
EP  - 205
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20221006.14
AB  - Naturally, Anxiety is a public disorder of high co-morbidity related to epilepsy, an enduring neurologic disease considered by persistent seizures. Existing drugs used for these situations have some restrictions for example spiking side effects, deterioration, and ineptness in certain people needing the look for other possibilities. The aqueous extract of Draceana reflexa leaves is broadly used for its several health-promoting effects with release of seizures and anxiety in ethnomedicine. Medicinal plants used for the epilepsy therapy have been systematically revealed to own hopeful anticonvulsant and anxiolytic effects during the anticonvulsant activity in animal experiments and can be a basis of fresher antiepileptics. Then, Draceana reflexa as a plant which belongs to the Asparagaceae family has been used in traditional medicine in Congo Republic for treating epilepsy and anxiety. Therefore, the current research work aimed to assess anticonvulsant and anxiolytic effect of Draceana reflexa including its mechanism on severe and long-lasting administration when using rats. Extracts of Draceana reflexa leaves were investigated for anticonvulsant effect induced seizures in rats at doses of 50,100 and 200 mg/Kg, respectively. The results found indicated that the extract of Draceaena reflexa leaves at all doses increases and decreases significantly the time of onset and the duration of convulsions respectively. Draceaena reflexa aqueous extract shows also a significant decrease in motor activity as does Diazepam and an increase in the immobility time by using the forced swimming test. This study suggests that Draceaena reflexa leaves considering social interaction-promoting effect might be of profit as an accessory in refining the life superiority of epileptic patients.
VL  - 10
IS  - 6
ER  -

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