Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus

Asmaa Saadoun; Mahmoud Rajab; Habib Yousef

doi:doi:10.11648/j.ajbls.20200806.14

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Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus

Asmaa Saadoun, Mahmoud Rajab, Habib Yousef

Published in American Journal of Biomedical and Life Sciences (Volume 8, Issue 6)

Received: 7 July 2020 Accepted: 22 July 2020 Published: 4 December 2020

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Abstract

Background: Retinopathy is a severe and common complication of diabetes. The pathology seems to be characterized not only by the involvement of retinal micro vessels but also by a real neuropathy. Before the onset of micro vascular lesions, the retina of the eye undergoes subtle functional changes that are not detectable by fundus photography. Electrophysiological investigations allow a more detailed study of the visual function. These techniques are safe, repeatable, quick, and objective. Objective: To study pattern electroretinogram (PERG) and pattern reversal visual evoked potentials (PRVEP) in type 2 diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative DR (mNPDR) to detect changes by comparing with those of healthy control. And to assess the correlation of the parameters with diabetes duration and the level of Glycosylated Haemoglobin A1c (HbA1c). Materials and Methods: It was a cross-sectional study, included two groups (diabetic patients and the healthy). Age range was preset at 40-65 years. For all the participants, a detailed clinical history was collected, a comprehensive ophthalmic examination and thorough blood investigations were performed, then {PRVEP (60', 15'), PERG} were recorded and (waveform, peak time, amplitude) of tests components were analyzed. Results: Mean (P100, N135) peak times of PRVEP were statistically significantly delayed in (50) eyes of type 2 diabetics without DR when compared to (36) eyes of control (p-value<0.01), abnormalities in waveforms like (double peaks, broad peak) were also observed in diabetics. There were alterations in other parameters (amplitudes of PRVEP, peak times and amplitudes of PERG) but the changes were not statistically significant. No statistically significant changes were found in (6) eyes of diabetic patients with mNPDR. No statistically significant correlation was obtained between diabetes duration or the level of HbA1c and delay of peak times or reduce amplitudes in patients. Conclusions: Electrophysiological tests are sensitive and useful investigations for the early identification of visual dysfunctions before the development of overt retinopathy in type 2 diabetics. PRVEP is more sensitive than PERG to monitor alterations and it may be sufficient to screen the patients in this stage.

Published in	American Journal of Biomedical and Life Sciences (Volume 8, Issue 6)
DOI	10.11648/j.ajbls.20200806.14
Page(s)	212-219
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Diabetic Retinopathy, Pattern Reversal Visual Evoked Potentials, Pattern Electroretinogram, Diabetes Duration, Glycosylated Haemoglobin A1c

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APA Style

Asmaa Saadoun, Mahmoud Rajab, Habib Yousef. (2020). Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus. American Journal of Biomedical and Life Sciences, 8(6), 212-219. https://doi.org/10.11648/j.ajbls.20200806.14

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ACS Style

Asmaa Saadoun; Mahmoud Rajab; Habib Yousef. Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus. Am. J. Biomed. Life Sci. 2020, 8(6), 212-219. doi: 10.11648/j.ajbls.20200806.14

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AMA Style

Asmaa Saadoun, Mahmoud Rajab, Habib Yousef. Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus. Am J Biomed Life Sci. 2020;8(6):212-219. doi: 10.11648/j.ajbls.20200806.14

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@article{10.11648/j.ajbls.20200806.14,
  author = {Asmaa Saadoun and Mahmoud Rajab and Habib Yousef},
  title = {Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {6},
  pages = {212-219},
  doi = {10.11648/j.ajbls.20200806.14},
  url = {https://doi.org/10.11648/j.ajbls.20200806.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200806.14},
  abstract = {Background: Retinopathy is a severe and common complication of diabetes. The pathology seems to be characterized not only by the involvement of retinal micro vessels but also by a real neuropathy. Before the onset of micro vascular lesions, the retina of the eye undergoes subtle functional changes that are not detectable by fundus photography. Electrophysiological investigations allow a more detailed study of the visual function. These techniques are safe, repeatable, quick, and objective. Objective: To study pattern electroretinogram (PERG) and pattern reversal visual evoked potentials (PRVEP) in type 2 diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative DR (mNPDR) to detect changes by comparing with those of healthy control. And to assess the correlation of the parameters with diabetes duration and the level of Glycosylated Haemoglobin A1c (HbA1c). Materials and Methods: It was a cross-sectional study, included two groups (diabetic patients and the healthy). Age range was preset at 40-65 years. For all the participants, a detailed clinical history was collected, a comprehensive ophthalmic examination and thorough blood investigations were performed, then {PRVEP (60', 15'), PERG} were recorded and (waveform, peak time, amplitude) of tests components were analyzed. Results: Mean (P100, N135) peak times of PRVEP were statistically significantly delayed in (50) eyes of type 2 diabetics without DR when compared to (36) eyes of control (p-valueConclusions: Electrophysiological tests are sensitive and useful investigations for the early identification of visual dysfunctions before the development of overt retinopathy in type 2 diabetics. PRVEP is more sensitive than PERG to monitor alterations and it may be sufficient to screen the patients in this stage.},
 year = {2020}
}

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TY  - JOUR
T1  - Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus
AU  - Asmaa Saadoun
AU  - Mahmoud Rajab
AU  - Habib Yousef
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200806.14
DO  - 10.11648/j.ajbls.20200806.14
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 212
EP  - 219
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200806.14
AB  - Background: Retinopathy is a severe and common complication of diabetes. The pathology seems to be characterized not only by the involvement of retinal micro vessels but also by a real neuropathy. Before the onset of micro vascular lesions, the retina of the eye undergoes subtle functional changes that are not detectable by fundus photography. Electrophysiological investigations allow a more detailed study of the visual function. These techniques are safe, repeatable, quick, and objective. Objective: To study pattern electroretinogram (PERG) and pattern reversal visual evoked potentials (PRVEP) in type 2 diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative DR (mNPDR) to detect changes by comparing with those of healthy control. And to assess the correlation of the parameters with diabetes duration and the level of Glycosylated Haemoglobin A1c (HbA1c). Materials and Methods: It was a cross-sectional study, included two groups (diabetic patients and the healthy). Age range was preset at 40-65 years. For all the participants, a detailed clinical history was collected, a comprehensive ophthalmic examination and thorough blood investigations were performed, then {PRVEP (60', 15'), PERG} were recorded and (waveform, peak time, amplitude) of tests components were analyzed. Results: Mean (P100, N135) peak times of PRVEP were statistically significantly delayed in (50) eyes of type 2 diabetics without DR when compared to (36) eyes of control (p-valueConclusions: Electrophysiological tests are sensitive and useful investigations for the early identification of visual dysfunctions before the development of overt retinopathy in type 2 diabetics. PRVEP is more sensitive than PERG to monitor alterations and it may be sufficient to screen the patients in this stage.
VL  - 8
IS  - 6
ER  -

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Author Information

Asmaa Saadoun

Ophthalmology Department, Tishreen Hospital, Faculty of Medicine, Tishreen University, Lattakia, Syria
Mahmoud Rajab

Ophthalmology Department, Tishreen Hospital, Faculty of Medicine, Tishreen University, Lattakia, Syria
Habib Yousef

Ophthalmology Department, Tishreen Hospital, Faculty of Medicine, Tishreen University, Lattakia, Syria

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APA Style

Asmaa Saadoun, Mahmoud Rajab, Habib Yousef. (2020). Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus. American Journal of Biomedical and Life Sciences, 8(6), 212-219. https://doi.org/10.11648/j.ajbls.20200806.14

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ACS Style

Asmaa Saadoun; Mahmoud Rajab; Habib Yousef. Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus. Am. J. Biomed. Life Sci. 2020, 8(6), 212-219. doi: 10.11648/j.ajbls.20200806.14

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AMA Style

Asmaa Saadoun, Mahmoud Rajab, Habib Yousef. Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus. Am J Biomed Life Sci. 2020;8(6):212-219. doi: 10.11648/j.ajbls.20200806.14

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@article{10.11648/j.ajbls.20200806.14,
  author = {Asmaa Saadoun and Mahmoud Rajab and Habib Yousef},
  title = {Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {6},
  pages = {212-219},
  doi = {10.11648/j.ajbls.20200806.14},
  url = {https://doi.org/10.11648/j.ajbls.20200806.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200806.14},
  abstract = {Background: Retinopathy is a severe and common complication of diabetes. The pathology seems to be characterized not only by the involvement of retinal micro vessels but also by a real neuropathy. Before the onset of micro vascular lesions, the retina of the eye undergoes subtle functional changes that are not detectable by fundus photography. Electrophysiological investigations allow a more detailed study of the visual function. These techniques are safe, repeatable, quick, and objective. Objective: To study pattern electroretinogram (PERG) and pattern reversal visual evoked potentials (PRVEP) in type 2 diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative DR (mNPDR) to detect changes by comparing with those of healthy control. And to assess the correlation of the parameters with diabetes duration and the level of Glycosylated Haemoglobin A1c (HbA1c). Materials and Methods: It was a cross-sectional study, included two groups (diabetic patients and the healthy). Age range was preset at 40-65 years. For all the participants, a detailed clinical history was collected, a comprehensive ophthalmic examination and thorough blood investigations were performed, then {PRVEP (60', 15'), PERG} were recorded and (waveform, peak time, amplitude) of tests components were analyzed. Results: Mean (P100, N135) peak times of PRVEP were statistically significantly delayed in (50) eyes of type 2 diabetics without DR when compared to (36) eyes of control (p-valueConclusions: Electrophysiological tests are sensitive and useful investigations for the early identification of visual dysfunctions before the development of overt retinopathy in type 2 diabetics. PRVEP is more sensitive than PERG to monitor alterations and it may be sufficient to screen the patients in this stage.},
 year = {2020}
}

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TY  - JOUR
T1  - Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus
AU  - Asmaa Saadoun
AU  - Mahmoud Rajab
AU  - Habib Yousef
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200806.14
DO  - 10.11648/j.ajbls.20200806.14
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 212
EP  - 219
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200806.14
AB  - Background: Retinopathy is a severe and common complication of diabetes. The pathology seems to be characterized not only by the involvement of retinal micro vessels but also by a real neuropathy. Before the onset of micro vascular lesions, the retina of the eye undergoes subtle functional changes that are not detectable by fundus photography. Electrophysiological investigations allow a more detailed study of the visual function. These techniques are safe, repeatable, quick, and objective. Objective: To study pattern electroretinogram (PERG) and pattern reversal visual evoked potentials (PRVEP) in type 2 diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative DR (mNPDR) to detect changes by comparing with those of healthy control. And to assess the correlation of the parameters with diabetes duration and the level of Glycosylated Haemoglobin A1c (HbA1c). Materials and Methods: It was a cross-sectional study, included two groups (diabetic patients and the healthy). Age range was preset at 40-65 years. For all the participants, a detailed clinical history was collected, a comprehensive ophthalmic examination and thorough blood investigations were performed, then {PRVEP (60', 15'), PERG} were recorded and (waveform, peak time, amplitude) of tests components were analyzed. Results: Mean (P100, N135) peak times of PRVEP were statistically significantly delayed in (50) eyes of type 2 diabetics without DR when compared to (36) eyes of control (p-valueConclusions: Electrophysiological tests are sensitive and useful investigations for the early identification of visual dysfunctions before the development of overt retinopathy in type 2 diabetics. PRVEP is more sensitive than PERG to monitor alterations and it may be sufficient to screen the patients in this stage.
VL  - 8
IS  - 6
ER  -

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