The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery

Radheshyam Gupta; Jiangfan Zhu; Yao Yang; Pamesh Jha; Rajesh Basnet; Ma Chiye

doi:doi:10.11648/j.ajhr.20221001.14

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The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery

Radheshyam Gupta, Jiangfan Zhu, Yao Yang, Pamesh Jha, Rajesh Basnet, Ma Chiye

Published in American Journal of Health Research (Volume 10, Issue 1)

Received: 29 December 2021 Accepted: 21 January 2022 Published: 16 February 2022

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Abstract

Background: The purpose of our study was to analyze the clinical and biochemical characteristics of obese patients with subclinical hypothyroidism (SCH). The study pertains (shown) to the clinical efficacy of bariatric surgery on sub-clinical thyroid function in obese patients. Methods: A total of 130 obese patients (M=24, F=106) who underwent bariatric surgery in our hospital between June 2018 and December 2019 were considered for the study. These patients were further divided into two sub-groups: SCH (22 cases) & NSCH (108 cases). The thyroid hormones and their relevant metabolic indexes were then subsequently compared using a t-test. The effect of the bariatric surgery on the SCH group was then analyzed. Results: Among 130 cases, the prevalence of the SCH group was in 22 patients accounting for 16.92%. The prevalence of SCH with metabolic syndrome (MS) was in 13 patients accounting for 59.09%. The prevalence of NSCH with metabolic syndrome was seen in 30 cases accounting for 27.77%. Consequently, this indicates a significant disparity between these two groups (P<0.05). The SCH group patients were followed up for 12 months of surgery. The study showed that post-bariatric surgery the average TSH level (6.07±1.68IU/mL) had drastically dropped (2.88±0.56 IU/mL) indicating a staggering statistical improvement amongst the SCH group (P<0.05). Conclusion: The study showed that the obese patients associated with Subclinical hypothyroidism who underwent bariatric surgery saw a significant reduction and improvement in their TSH levels. The prevalence of subclinical hypothyroidism in the SCH group of obese patients was 16.92%. There was a higher MS occurrence rate amongst SCH patients. SCH could is a type of metabolic syndrome. Post-bariatric surgery has shown a significant decrease in TSH levels and acts as an effective treatment for SCH in obese patients.

Published in	American Journal of Health Research (Volume 10, Issue 1)
DOI	10.11648/j.ajhr.20221001.14
Page(s)	20-23
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Subclinical Hypothyroidism, Bariatric Surgery, Metabolic Syndrome, Morbid Obesity, Laparoscopic Sleeve Gastrectomy

References

[1]	DiBaise JK, Foxx-Orenstein AE: Role of the gastroenterologist in managing obesity. Expert review of gastroenterology & hepatology 2013, 7 (5): 439-451.
[2]	Hruby A, Hu FB: The epidemiology of obesity: a big picture. Pharmacoeconomics 2015, 33 (7): 673-689.
[3]	Hurt RT, Kulisek C, Buchanan LA, McClave SA: The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists. Gastroenterology & hepatology 2010, 6 (12): 780.
[4]	Ofei F: Obesity-a preventable disease. Ghana medical journal 2005, 39 (3): 98.
[5]	Helble M, Sato A: Wealthy but Unhealthy Overweight and Obesity in Asia and the Pacific: Trends, Costs, and Policies for Better Health: Asian Development Bank Institute; 2018.
[6]	Gupta R, Bhagat S, Zhu J, Shrestha P: The Prevalence of Subclinical Hypothyroidism and its Effect after Bariatric Surgery: A Review. Biomedical Letters 2017, 3 (1): 10-16.
[7]	Kyrou I, Randeva HS, Tsigos C, Kaltsas G, Weickert MO: Clinical problems caused by obesity. Endotext [Internet] 2018.
[8]	Arterburn DE, Courcoulas AP: Bariatric surgery for obesity and metabolic conditions in adults. Bmj 2014, 349.
[9]	Davis JD, Stern RA, Flashman LA: Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly. Current psychiatry reports 2003, 5 (5): 384-390.
[10]	Rugge B, Balshem H, Sehgal R, Relevo R, Gorman P, Helfand M: Screening and treatment of subclinical hypothyroidism or hyperthyroidism. 2012.
[11]	Buchwald H, Oien DM: Metabolic/bariatric surgery worldwide 2008. Obesity surgery 2009, 19 (12): 1605-1611.
[12]	Hosur MB, Puranik R, Vanaki S, Puranik SR: Study of thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in subjects with dental fluorosis. European journal of dentistry 2012, 6 (2): 184.
[13]	Aghajanova L, Stavreus-Evers A, Lindeberg M, Landgren B-M, Sparre LS, Hovatta O: Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology. Fertility and sterility 2011, 95 (1): 230-237. e232.
[14]	Rotondi M, Leporati P, La Manna A, Pirali B, Mondello T, Fonte R, Magri F, Chiovato L: Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? European Journal of Endocrinology 2009, 160 (3): 403.
[15]	De Moraes CMM, Mancini MC, de Melo ME, Figueiredo DA, Villares SMF, Rascovski A, Zilberstein B, Halpern A: Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass. Obesity surgery 2005, 15 (9): 1287-1291.
[16]	Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, Jørgensen T: Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. The Journal of Clinical Endocrinology & Metabolism 2005, 90 (7): 4019-4024.
[17]	Nyrnes A, Jorde R, Sundsfjord J: Serum TSH is positively associated with BMI. International journal of obesity 2006, 30 (1): 100-105.
[18]	Ambrosi B, Masserini B, Iorio L, Delnevo A, Malavazos A, Morricone L, Sburlati L, Orsi E: Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects. Journal of endocrinological investigation 2010, 33 (9): 640-643.
[19]	Shaikh MG, Grundy RG, Kirk JM: Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothalamic damage in children. European journal of endocrinology 2008, 159 (6): 791.
[20]	Radetti G, Kleon W, Buzi F, Crivellaro C, Pappalardo L, Di Iorgi N, Maghnie M: Thyroid function and structure are affected in childhood obesity. The Journal of Clinical Endocrinology & Metabolism 2008, 93 (12): 4749-4754.
[21]	Mullur R, Liu Y-Y, Brent GA: Thyroid hormone regulation of metabolism. Physiological reviews 2014, 94 (2): 355-382.
[22]	Waring AC, Rodondi N, Harrison S, Kanaya AM, Simonsick EM, Miljkovic I, Satterfield S, Newman AB, Bauer DC, Health A et al: Thyroid function and prevalent and incident metabolic syndrome in older adults: the Health, Ageing and Body Composition Study. Clinical endocrinology 2012, 76 (6): 911-918.

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APA Style

Radheshyam Gupta, Jiangfan Zhu, Yao Yang, Pamesh Jha, Rajesh Basnet, et al. (2022). The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery. American Journal of Health Research, 10(1), 20-23. https://doi.org/10.11648/j.ajhr.20221001.14

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ACS Style

Radheshyam Gupta; Jiangfan Zhu; Yao Yang; Pamesh Jha; Rajesh Basnet, et al. The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery. Am. J. Health Res. 2022, 10(1), 20-23. doi: 10.11648/j.ajhr.20221001.14

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AMA Style

Radheshyam Gupta, Jiangfan Zhu, Yao Yang, Pamesh Jha, Rajesh Basnet, et al. The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery. Am J Health Res. 2022;10(1):20-23. doi: 10.11648/j.ajhr.20221001.14

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@article{10.11648/j.ajhr.20221001.14,
  author = {Radheshyam Gupta and Jiangfan Zhu and Yao Yang and Pamesh Jha and Rajesh Basnet and Ma Chiye},
  title = {The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery},
  journal = {American Journal of Health Research},
  volume = {10},
  number = {1},
  pages = {20-23},
  doi = {10.11648/j.ajhr.20221001.14},
  url = {https://doi.org/10.11648/j.ajhr.20221001.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20221001.14},
  abstract = {Background: The purpose of our study was to analyze the clinical and biochemical characteristics of obese patients with subclinical hypothyroidism (SCH). The study pertains (shown) to the clinical efficacy of bariatric surgery on sub-clinical thyroid function in obese patients. Methods: A total of 130 obese patients (M=24, F=106) who underwent bariatric surgery in our hospital between June 2018 and December 2019 were considered for the study. These patients were further divided into two sub-groups: SCH (22 cases) & NSCH (108 cases). The thyroid hormones and their relevant metabolic indexes were then subsequently compared using a t-test. The effect of the bariatric surgery on the SCH group was then analyzed. Results: Among 130 cases, the prevalence of the SCH group was in 22 patients accounting for 16.92%. The prevalence of SCH with metabolic syndrome (MS) was in 13 patients accounting for 59.09%. The prevalence of NSCH with metabolic syndrome was seen in 30 cases accounting for 27.77%. Consequently, this indicates a significant disparity between these two groups (P<0.05). The SCH group patients were followed up for 12 months of surgery. The study showed that post-bariatric surgery the average TSH level (6.07±1.68IU/mL) had drastically dropped (2.88±0.56 IU/mL) indicating a staggering statistical improvement amongst the SCH group (P<0.05). Conclusion: The study showed that the obese patients associated with Subclinical hypothyroidism who underwent bariatric surgery saw a significant reduction and improvement in their TSH levels. The prevalence of subclinical hypothyroidism in the SCH group of obese patients was 16.92%. There was a higher MS occurrence rate amongst SCH patients. SCH could is a type of metabolic syndrome. Post-bariatric surgery has shown a significant decrease in TSH levels and acts as an effective treatment for SCH in obese patients.},
 year = {2022}
}

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TY - JOUR
T1 - The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery
AU - Radheshyam Gupta
AU - Jiangfan Zhu
AU - Yao Yang
AU - Pamesh Jha
AU - Rajesh Basnet
AU - Ma Chiye
Y1 - 2022/02/16
PY - 2022
N1 - https://doi.org/10.11648/j.ajhr.20221001.14
DO - 10.11648/j.ajhr.20221001.14
T2 - American Journal of Health Research
JF - American Journal of Health Research
JO - American Journal of Health Research
SP - 20
EP - 23
PB - Science Publishing Group
SN - 2330-8796
UR - https://doi.org/10.11648/j.ajhr.20221001.14
AB - Background: The purpose of our study was to analyze the clinical and biochemical characteristics of obese patients with subclinical hypothyroidism (SCH). The study pertains (shown) to the clinical efficacy of bariatric surgery on sub-clinical thyroid function in obese patients. Methods: A total of 130 obese patients (M=24, F=106) who underwent bariatric surgery in our hospital between June 2018 and December 2019 were considered for the study. These patients were further divided into two sub-groups: SCH (22 cases) & NSCH (108 cases). The thyroid hormones and their relevant metabolic indexes were then subsequently compared using a t-test. The effect of the bariatric surgery on the SCH group was then analyzed. Results: Among 130 cases, the prevalence of the SCH group was in 22 patients accounting for 16.92%. The prevalence of SCH with metabolic syndrome (MS) was in 13 patients accounting for 59.09%. The prevalence of NSCH with metabolic syndrome was seen in 30 cases accounting for 27.77%. Consequently, this indicates a significant disparity between these two groups (P<0.05). The SCH group patients were followed up for 12 months of surgery. The study showed that post-bariatric surgery the average TSH level (6.07±1.68IU/mL) had drastically dropped (2.88±0.56 IU/mL) indicating a staggering statistical improvement amongst the SCH group (P<0.05). Conclusion: The study showed that the obese patients associated with Subclinical hypothyroidism who underwent bariatric surgery saw a significant reduction and improvement in their TSH levels. The prevalence of subclinical hypothyroidism in the SCH group of obese patients was 16.92%. There was a higher MS occurrence rate amongst SCH patients. SCH could is a type of metabolic syndrome. Post-bariatric surgery has shown a significant decrease in TSH levels and acts as an effective treatment for SCH in obese patients.
VL - 10
IS - 1
ER -

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Author Information

Radheshyam Gupta

Department of General Surgery, Nepal Korea Friendship Municipality Hospital, Bhaktapur, Nepal
Jiangfan Zhu

Bariatric and Metabolic Surgery, East Hospital, Tongji University School of Medicine, Shanghai, China
Yao Yang

Bariatric and Metabolic Surgery, East Hospital, Tongji University School of Medicine, Shanghai, China
Pamesh Jha

Department of General Surgery, Nepal Korea Friendship Municipality Hospital, Bhaktapur, Nepal
Rajesh Basnet

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Ma Chiye

Bariatric and Metabolic Surgery, East Hospital, Tongji University School of Medicine, Shanghai, China

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APA Style

Radheshyam Gupta, Jiangfan Zhu, Yao Yang, Pamesh Jha, Rajesh Basnet, et al. (2022). The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery. American Journal of Health Research, 10(1), 20-23. https://doi.org/10.11648/j.ajhr.20221001.14

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ACS Style

Radheshyam Gupta; Jiangfan Zhu; Yao Yang; Pamesh Jha; Rajesh Basnet, et al. The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery. Am. J. Health Res. 2022, 10(1), 20-23. doi: 10.11648/j.ajhr.20221001.14

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AMA Style

Radheshyam Gupta, Jiangfan Zhu, Yao Yang, Pamesh Jha, Rajesh Basnet, et al. The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery. Am J Health Res. 2022;10(1):20-23. doi: 10.11648/j.ajhr.20221001.14

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@article{10.11648/j.ajhr.20221001.14,
  author = {Radheshyam Gupta and Jiangfan Zhu and Yao Yang and Pamesh Jha and Rajesh Basnet and Ma Chiye},
  title = {The Prevalence of Subclinical Hypothyroidism in the Obese Population and Effect Following Bariatric Surgery},
  journal = {American Journal of Health Research},
  volume = {10},
  number = {1},
  pages = {20-23},
  doi = {10.11648/j.ajhr.20221001.14},
  url = {https://doi.org/10.11648/j.ajhr.20221001.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20221001.14},
  abstract = {Background: The purpose of our study was to analyze the clinical and biochemical characteristics of obese patients with subclinical hypothyroidism (SCH). The study pertains (shown) to the clinical efficacy of bariatric surgery on sub-clinical thyroid function in obese patients. Methods: A total of 130 obese patients (M=24, F=106) who underwent bariatric surgery in our hospital between June 2018 and December 2019 were considered for the study. These patients were further divided into two sub-groups: SCH (22 cases) & NSCH (108 cases). The thyroid hormones and their relevant metabolic indexes were then subsequently compared using a t-test. The effect of the bariatric surgery on the SCH group was then analyzed. Results: Among 130 cases, the prevalence of the SCH group was in 22 patients accounting for 16.92%. The prevalence of SCH with metabolic syndrome (MS) was in 13 patients accounting for 59.09%. The prevalence of NSCH with metabolic syndrome was seen in 30 cases accounting for 27.77%. Consequently, this indicates a significant disparity between these two groups (P<0.05). The SCH group patients were followed up for 12 months of surgery. The study showed that post-bariatric surgery the average TSH level (6.07±1.68IU/mL) had drastically dropped (2.88±0.56 IU/mL) indicating a staggering statistical improvement amongst the SCH group (P<0.05). Conclusion: The study showed that the obese patients associated with Subclinical hypothyroidism who underwent bariatric surgery saw a significant reduction and improvement in their TSH levels. The prevalence of subclinical hypothyroidism in the SCH group of obese patients was 16.92%. There was a higher MS occurrence rate amongst SCH patients. SCH could is a type of metabolic syndrome. Post-bariatric surgery has shown a significant decrease in TSH levels and acts as an effective treatment for SCH in obese patients.},
 year = {2022}
}

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