Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh

S. K. Jakaria Been Sayeed; Md. Mujibur Rahman; A. K. M. Humayon Kabir; Md. Moniruzzaman; Reaz Mahmud; Mohammad Abdullah Yusuf; Sabrina Rahman

doi:doi:10.11648/j.ajim.20210901.12

Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh

S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, Mohammad Abdullah Yusuf, Sabrina Rahman

Published in American Journal of Internal Medicine (Volume 9, Issue 1)

Received: 18 December 2020 Accepted: 30 December 2020 Published: 15 January 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.

Published in	American Journal of Internal Medicine (Volume 9, Issue 1)
DOI	10.11648/j.ajim.20210901.12
Page(s)	11-16
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

SARS-CoV-2, COVID-19, Pregnancy, Outcome

References

[1]	Guan W, Ni Z, Hu Y, et al. Clinical characteristics of corona virus disease 2019 in China. N Engl J Med 2020; 382: 1708-1720. 10.1056/NEJMoa2002032.
[2]	Guo ZD, Wang ZY, Zhang SF, et al. Aerosol and Surface Distribution of Severe Acute Respiratory Syndrome Corona virus 2 in Hospital Wards, Wuhan, China, 2020. Emerging Infect. Dis. 2020; 26 (7): 1583-1591.10.3201/eid2607.200885.
[3]	Cascella M, Rajnik M, Cuomo A, et al. Features, Evaluation and Treatment Corona virus (COVID-19) [Updated 2020 Jul 4]. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554776.
[4]	Zhu J, Ji P, Pang J, et al. Clinical characteristics of 3062 COVID-19 patients: A meta analysis. J Med Virol. 2020.92: 1902-1914. 10.1002/jmv.25884.
[5]	Wang D, Li FR, Wang J, et al. Association between severity of COVID-19 and clinical and biochemical characteristics: a cross-sectional Study, Research square: infectious disease [preprint]. 10.21203/rs.3.rs-18482/v1.
[6]	Contreras G, Gutiérrez M, Beroíza T, et al. Ventilatory drive and respiratory muscle function in pregnancy. Am Rev Respir Dis. 1991; 144: 837–41. https://doi.org/10.1164/ajrccm/144.4.
[7]	Lederman MM. Cell-mediated immunity and pregnancy [J]. Chest. 1984; 86: 6S-9S.https://doi.org/10.1186/s12884-020-03026-3.
[8]	WHO guidance on management of severe acute respiratory infection (SARI) when COVID19 is suspected; https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected.
[9]	National Guidelines on Clinical Management of Coronavirus Disease 2019 (Covid-19), 27 May, 2020 https://dghs.gov.bd/images/docs/Guideline/COVID_Guideline.pdf.
[10]	Zhang, L., Dong, L., Ming, L. et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during late pregnancy: a report of 18 patients from Wuhan, China. BMC Pregnancy Childbirth 20, 394 (2020). https://doi.org/10.1186/s12884-020-03026-3.
[11]	Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5.
[12]	Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99 (7): 823-829. 10.1111/aogs.13867.
[13]	San-Juana R, Barberob P, Fernandez-Ruiz M, et al. Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain. Eclinical medicine. 2020; 23: 100407. https://doi.org/10.1016/j.eclinm.2020.100407.
[14]	Martínez-Perez O, Vouga M, Cruz Melguizo S, et al. Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain [published online ahead of print, 2020 Jun 8] [published correction appears in JAMA. 2020 21; 324 (3): 305]. JAMA. 2020; e2010125. 10.1001/jama.2020.10125.
[15]	Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost. 2020; 18: 1648-1652.10.1111/jth.14856.
[16]	Lei J, Li J, Li X, et al. CT Imaging of the 2019 novel coronavirus (COVID-19) pneumonia [J]. Radiology. 2020; 31: 200236. https://doi.org/10.1148/radiol.2020200236.

Cite This Article

Plain Text BibTeX RIS

APA Style

S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, et al. (2021). Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. American Journal of Internal Medicine, 9(1), 11-16. https://doi.org/10.11648/j.ajim.20210901.12

Copy | Download

ACS Style

S. K. Jakaria Been Sayeed; Md. Mujibur Rahman; A. K. M. Humayon Kabir; Md. Moniruzzaman; Reaz Mahmud, et al. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. Am. J. Intern. Med. 2021, 9(1), 11-16. doi: 10.11648/j.ajim.20210901.12

Copy | Download

AMA Style

S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, et al. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. Am J Intern Med. 2021;9(1):11-16. doi: 10.11648/j.ajim.20210901.12

Copy | Download

@article{10.11648/j.ajim.20210901.12,
  author = {S. K. Jakaria Been Sayeed and Md. Mujibur Rahman and A. K. M. Humayon Kabir and Md. Moniruzzaman and Reaz Mahmud and Mohammad Abdullah Yusuf and Sabrina Rahman},
  title = {Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {1},
  pages = {11-16},
  doi = {10.11648/j.ajim.20210901.12},
  url = {https://doi.org/10.11648/j.ajim.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210901.12},
  abstract = {Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh
AU  - S. K. Jakaria Been Sayeed
AU  - Md. Mujibur Rahman
AU  - A. K. M. Humayon Kabir
AU  - Md. Moniruzzaman
AU  - Reaz Mahmud
AU  - Mohammad Abdullah Yusuf
AU  - Sabrina Rahman
Y1  - 2021/01/15
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210901.12
DO  - 10.11648/j.ajim.20210901.12
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 11
EP  - 16
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210901.12
AB  - Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.
VL  - 9
IS  - 1
ER  -

Copy | Download

Author Information

S. K. Jakaria Been Sayeed

Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh
Md. Mujibur Rahman

Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh
A. K. M. Humayon Kabir

Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh
Md. Moniruzzaman

Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
Reaz Mahmud

Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh
Mohammad Abdullah Yusuf

Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
Sabrina Rahman

Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, et al. (2021). Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. American Journal of Internal Medicine, 9(1), 11-16. https://doi.org/10.11648/j.ajim.20210901.12

Copy | Download

ACS Style

S. K. Jakaria Been Sayeed; Md. Mujibur Rahman; A. K. M. Humayon Kabir; Md. Moniruzzaman; Reaz Mahmud, et al. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. Am. J. Intern. Med. 2021, 9(1), 11-16. doi: 10.11648/j.ajim.20210901.12

Copy | Download

AMA Style

S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, et al. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. Am J Intern Med. 2021;9(1):11-16. doi: 10.11648/j.ajim.20210901.12

Copy | Download

@article{10.11648/j.ajim.20210901.12,
  author = {S. K. Jakaria Been Sayeed and Md. Mujibur Rahman and A. K. M. Humayon Kabir and Md. Moniruzzaman and Reaz Mahmud and Mohammad Abdullah Yusuf and Sabrina Rahman},
  title = {Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {1},
  pages = {11-16},
  doi = {10.11648/j.ajim.20210901.12},
  url = {https://doi.org/10.11648/j.ajim.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210901.12},
  abstract = {Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh
AU  - S. K. Jakaria Been Sayeed
AU  - Md. Mujibur Rahman
AU  - A. K. M. Humayon Kabir
AU  - Md. Moniruzzaman
AU  - Reaz Mahmud
AU  - Mohammad Abdullah Yusuf
AU  - Sabrina Rahman
Y1  - 2021/01/15
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210901.12
DO  - 10.11648/j.ajim.20210901.12
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 11
EP  - 16
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210901.12
AB  - Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.
VL  - 9
IS  - 1
ER  -

Copy | Download