@article{10.11648/j.ajpn.20221003.15,
  author = {Michael Raymond Binder},
  title = {Suicide: A New Hypothesis on the Pathogenesis of Disease, Method of Screening, and Means of Prevention},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {10},
  number = {3},
  pages = {111-124},
  doi = {10.11648/j.ajpn.20221003.15},
  url = {https://doi.org/10.11648/j.ajpn.20221003.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221003.15},
  abstract = {Suicide has become a global epidemic. Every 40 seconds, another person completes the act, and for every person who successfully commits suicide, there are many more who attempt to take their lives. Although many factors are known to increase the risk of suicide, there continues to be a lack of clarity about why some persons decide to end their lives and, equally disturbing, a lack of predictability about when they decide to end their lives. However, an emerging hypothesis contends that a subtle but highly prevalent neurophysiological abnormality is at the root of nearly all psychopathology, including suicidal thinking and behavior. According to the multi-circuit neuronal hyperexcitability hypothesis of psychiatric disorders, an inherent hyperexcitability of the neurological system causes normal thoughts and emotions to become abnormally amplified and persistent. Thus, persistent firing in anxiety circuits causes persistent feelings of anxiety; persistent firing in depressive circuits causes persistent feelings of depression; persistent firing in cognitive circuits causes ruminative and obsessive thoughts; etc... In addition to offering a biologically-based explanation for the development of psychiatric symptomatology, the severe emotional distress, loss of behavioral control, and waxing and waning of symptoms that this neurophysiological abnormality can create from an early age offers a highly plausible explanation for why an affected person might eventually attempt suicide and why the timing of that decision is so difficult to predict. This article will trace the epidemic of suicide to its molecular roots and propose a simple, objective way to assess one’s vulnerability to suicide and an equally simple way to reduce that vulnerability before it is too late.},
 year = {2022}
}

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TY  - JOUR
T1  - Suicide: A New Hypothesis on the Pathogenesis of Disease, Method of Screening, and Means of Prevention
AU  - Michael Raymond Binder
Y1  - 2022/08/29
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpn.20221003.15
DO  - 10.11648/j.ajpn.20221003.15
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 111
EP  - 124
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20221003.15
AB  - Suicide has become a global epidemic. Every 40 seconds, another person completes the act, and for every person who successfully commits suicide, there are many more who attempt to take their lives. Although many factors are known to increase the risk of suicide, there continues to be a lack of clarity about why some persons decide to end their lives and, equally disturbing, a lack of predictability about when they decide to end their lives. However, an emerging hypothesis contends that a subtle but highly prevalent neurophysiological abnormality is at the root of nearly all psychopathology, including suicidal thinking and behavior. According to the multi-circuit neuronal hyperexcitability hypothesis of psychiatric disorders, an inherent hyperexcitability of the neurological system causes normal thoughts and emotions to become abnormally amplified and persistent. Thus, persistent firing in anxiety circuits causes persistent feelings of anxiety; persistent firing in depressive circuits causes persistent feelings of depression; persistent firing in cognitive circuits causes ruminative and obsessive thoughts; etc... In addition to offering a biologically-based explanation for the development of psychiatric symptomatology, the severe emotional distress, loss of behavioral control, and waxing and waning of symptoms that this neurophysiological abnormality can create from an early age offers a highly plausible explanation for why an affected person might eventually attempt suicide and why the timing of that decision is so difficult to predict. This article will trace the epidemic of suicide to its molecular roots and propose a simple, objective way to assess one’s vulnerability to suicide and an equally simple way to reduce that vulnerability before it is too late.
VL  - 10
IS  - 3
ER  - 

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