Plants are the backbone of the life on earth. They are essential resource for human well- being and among them Datura stramonium is one of highly important plants commonly known as Jimson weed. It is an annual herb found in temperate and sub-tropical areas. Its medicinal significance is mainly because of higher amounts of tropane alkaloids and traditionally used throughout the world. It possesses many phytoconstituents including alkaloids, flavonoids, amino acids, tannins, saponins, carbohydrates, terpenoids, steroidal glycosides and phenols. Various pharmacological activities i.e. anti-asthmatic, antimicrobial, antioxidant, anticancer and anti-inflammatory are exhibited by the plant. Secondary metabolites obtained from species of Datura genus produce tropane alkaloids which have influence on human nervous system and are used in medicines. Despite of its medicinal importance it is a potentially poisonous plant and known as plant hallucinogen. Its random use can cause restlessness and acute poisoning may lead to death. In global increasing energy demand scenario, Datura stramonium plant seeds oil is proved as an efficient source for biodiesel production. This paper will present an exclusive review with respect to the phytochemicals, ethno-medicinal, pharmacological and biotechnological aspects which will lay a solid foundation for further scientific research work to exploit the medicinal and industrial benefits of this plant.
| Published in | Journal of Plant Sciences (Volume 8, Issue 2) |
| DOI | 10.11648/j.jps.20200802.12 |
| Page(s) | 29-40 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Datura stramonium, Jimson Weed, Tropane Alkaloids, Phytochemicals, Pharmacology, Biotechnology
| [1] | Abdollahi, M., H. Karimpour and H. P. Monsef-esfehani. 2003. Antinociceptive effects of Teucrium polium L. total extracts and essential oil in mouse writhing test. Pharmacology. 3 (8): 21-26. |
| [2] | Ahmed, I., M. Y. Abdullah, N. H. Mustafa, E. Y. Qnais and F. A. Abdullah. 2009. Datura aqueous leaf extracts enhances cytotoxicity, metabolic oxidative stress on different human cancer cells. Journal of Biological Sciences. 2 (1): 9-14. |
| [3] | Altameme, H. J., I. H. Hameed and M. A. Kareem. 2015. Analysis of alkaloid phytochemical compounds in the ethanolic extract of Datura stramonium and evaluation of antimicrobial activity. African Journal of Botany. 14 (19): 1668-1674. |
| [4] | Ashutosh G. 2020. Experimental investigation of Datura Stramonium biodiesel. International Journal of Advance Research, Ideas and Innovations in Technology, 6 (2). |
| [5] | Bazaoui, A. E., M. A. Bellimam and A. Soulaymani. 2011. Nine new tropane alkaloids from Datura stramonium L. identified by GC-MS. Fitoterapia. 82 (2): 193-197. |
| [6] | Berkov, S., R. Zaved and T. Douncheva. 2006. Alkaloid patterns in some varieties of Datura stramonium. Filoterapia. 77: 179-182. |
| [7] | Bellakhdar, J. 1997. La pharmacopee marcaine traditionnelle. Saint-etime, Iberis press, pp: 494-496. |
| [8] | Berkov, S., A. Parlov, P. Kovacheva, P. Stanimirora and S. Philipov. 2003. Alkaloid spectrum in diploid and tetraploid root cultures of Datura stramonium. Z Naturfrosch C. 58: 42-46. |
| [9] | Biren, S. 2009. Textbook of pharmacognosy and phytochemistry. Elslevier-health sciences. pp: 193. |
| [10] | Binev, R., I. Valchev and J. Nikolov. 2006. Clinical and pathological studies of Jimson weed poisoning in horses. Turkia Journal of Sciences. 4 (3): 56-63. |
| [11] | Blossey, J. W., H. Budzikiwics, M. Ohashi, G. Fodor and C. Djerassi. 1964. Mass spectrometry in structural and sterochemical problems-XXXIX tropanealkaloids. Tetrahedron. 20: 585-595. |
| [12] | Couladis, M., O. Tzakon, E. Verykokidou and C. Harvala. 2003. Screening of some Greek aromatic plants for antioxidant activity. Phytotherapy Research. 17: 194-195. |
| [13] | Clapham, A. R., T. G. Tutin and D. M. Moore. 1987. Flora of British Isles, 3rd edition. Cambridge university press, Cambridge UK. |
| [14] | Das, B. K. Mukherjee, S. C. 2003. Toxicity of cypermethrin toxin in Labeo rohita fingerlings: biochemical, enzymatic, haematological consequences. Comp biochem physio part c toxicol pharmacol. 134 (1), pp: 109-121. |
| [15] | Das, S., P. Kumar and S. P. Basu. 2012. Review article on phytoconstituents and therapeutic potentials of Datura stramonium. J. Drug. Del. Therap. 2: 4-7. |
| [16] | Dessanges, J. F. 2001. A history of nebulization. J. Aerosol. Med. 14 (1): 65-71. |
| [17] | Deshmukh, A. S., P. D. Shelke, K. S. Palekar, S. D. Pawar and H. S. Shindes. 2015. Antimicrobial investigations of Datura stramonium leaf extracts against different microorganisms. IOSR Journal of environmental science, toxicology and food technology. 9 (9): 17-19. |
| [18] | Doncheva, T., S. Philipov and N. Kostova. 2004. Alkaloids of Datura stramonium L. competes Rendus de ‘I’ academic Bulgare de Sciences. 57: 41-44. |
| [19] | Dugan, G. M., M. R. Gumbmann and M. Friedmann. 1989. Toxicological evaluation of Jimson weed seed. Food and Chemical Toxicology. 27 (8): 501-510. |
| [20] | Ekanem, P. E., R. Ekanem and K. Gaim. 2016. Histological patterns of neurodegeneration of frontal cortex neurons in Datura stramonium treated Wistar Rats. Journal of Behavioral and Brain Sciences. 6: 85-92. |
| [21] | Evan, W. and J. Lampard. 1972. Alkaloids of Datura suoveolens. Phytochemistry. 11: 3293-3298. |
| [22] | Evans, W. C. and K. P. Ramsey. 1981. Tropane alkaloids from anthocercis and anthotroche. Phytochemistry. 20: 497-499. |
| [23] | Friedman, M. and C. E. Levin. 1989. Composition of Jimson Weed seed. Journal of agriculture and food chemistry. 37: 998-1005. |
| [24] | Gachande, B. D. and E. M. Khillare. 2013. Invitro evaluation of Datura species for potential antimicrobial activity. Biosci Discov. 4 (1): 78-81. |
| [25] | Ganesan, K., S. K. P. Nair, H. G. Azaleusor, N. Letha and S. B. Ghani. 2016. Preliminary phytochemical screening and in- vitro antioxidant activity of Datura stramonium collected from Jimmah, South West Ethiopia. International Journal of Pharma and Bio Sciences. 7 (1): 261-266. |
| [26] | Ghaida, J. M., H. H. Imad and K. A. Sabreen. 2016. Study of secondary metabolites produced by Aspergillus flavus and evaluation of antifungal and antibacterial activity. African Journal of Biotechnology. 2 (6): 18-25. |
| [27] | Gharaibeh, M. N., H. H. Elayan and A. S. Salhab. 1998. Hypoglycemic effects of Teucrium polium. Journal of ethnopharmacology. 24: 93-99. |
| [28] | Ghani, A. and A. M. Pindiga. 1985. A comparative pharmacognostic study of two Nigerian Datura species. Nigerian jour of pharmaceutical sciences. pp: 31-36. |
| [29] | Gillard, J. W, H. M. Leon and N. W Preston. 1797. Alkaloid of Belledena montana family Potaceae. Australian Journal of chemistry. 32: 2071-2082. |
| [30] | Gorayeb, Eduardo S., Bello, Vinicius H., Cruciol, Giovana Carolina D., Watanabe, Luís Fernando M., Dovigo, Leonardo H., Sartori, Maria Márcia P., Krause-Sakate, Renate. (2020). Evaluation of Datura stramonium and Nicandra physaloides as reservoirs of tomato severe rugose virus and whiteflies. Plant Pathology, 69 (3), 569-575. doi: 10.1111/ppa.13139. |
| [31] | Gupta, D. P. 2008. The herb, habitat, morphology and pharmacognosy of most important medicinal plants. Printwell Offset publishers, Madhya Pardesh, 1st edition, pp: 185. |
| [32] | Gray, I., A. Strafford, K. Anna, B. Jager and V. S. Johannes. 2005. Activity of traditional South African sedative and potentially CNS acting plants of Gabba-benzodiazapine acceptor assay. J. Ethnopharm. pp: 201-215. |
| [33] | Hanson, C. G. and J. L. Mason. 1985. Bird seed aliens in Britain. Watsonia. pp: 237-252. |
| [34] | Habib, A., M. Mohammed, R. Fahimeh and H. H. Muhammad. 2011. Bioactivities of Jimson weed extracts of Datura stramonium against Tribolium casteneum. Turkish Journal of Agriculture and Forestry. 35: 623-629. |
| [35] | Harfi, Boualem, Khelifi, Lakhdar, Khelifi-Slaoui, Majda, Assaf-Ducrocq, Corinne, & Gontier, Eric. 2018. Tropane alkaloids GC/MS analysis and low dose elicitors’ effects on hyoscyamine biosynthetic pathway in hairy roots of Algerian Datura species. Scientific Reports, 8 (1), 17951. doi: 10.1038/s41598-018-36625-4. |
| [36] | Hong L., Z. Guo, K. Huang, S. Wei, B. Liu, S. Meng, C. Long. 2015. Ethnobotanical study on medicinal plants used by Maonan people in China. Journal of ethnobiology and ethnomedicine. 11 (32). |
| [37] | Kamal, M., M. Adnan, W. Murad, A. Bibi, A. Tariq, H. Rehman and Z. K. Shinwari. 2016. Anti-rheumatic potential of Pakistani medicinal plants: A review. Pak. J. Bot., 48 (1): 399-413. |
| [38] | Khan, S., A. Kamili and R. C. Gupta. 2016. Economic and medicinal properties of medicinal plants found in Kashmir Himalaya. Journal of Medicinal Plants Studies. 4 (3): 38-44. |
| [39] | Khandare, K. R. Salve, S. B. 2011. Management of wilt of pigeon pea (Cajanus cajan L.) through biopesticide (leaf extracts). Int Ref Res J. 2 (18). pp: 21-22. |
| [40] | Ionkov, I., L. Witte and H. A. Alfermann. 1994. Spectrum of tropane alkaloids in transformed roots of Datura innoxia and Hyoscyamus cultivated in vitro. Planta Medica. pp: 60. |
| [41] | Ivanov, I. and S. Nikalov. 1988. Tropane alkaloids in the pharmacognosy medicinal. Fizkuttura, Sofia. 351-355. |
| [42] | Jeralg, E. and S. Edvin. 2007. Text book of pharmacognosy and phytochemistry. CBS publishers and distributors, Newdehli, 1st edition, p: 224. |
| [43] | John, B. S. and S. Senthikumar. 2005. Antibacterial activity of Solanum incatum L. leaf extracts. Asian J. of Microb. Biotech. Environmental Sciences. 3: 65-66. |
| [44] | Khan and Yadaba. 2010. Herbal remedies of asthma in Thoubal District of Manipur in North East India. Indian Journal of natural products and resources. 1 (1): 80-84. |
| [45] | Kumar, V. P., S. Shashidra, M. M. Kumar and B. Y Sridhara. 2001. Cytoprotective role of Datura species against gentamicin-induced kidney cell (vero) cells damage in vitro. Fitoterapia. 72: 481-486. |
| [46] | Kumral, N. A., C. Sultan, C. Yalcin. 2010. Acaricidal and oviposition deterrent properties of Datura stramonium against adult Tatranychus utricae (Koch). Journal of Pest Science. 83: 173-180. |
| [47] | Kumar, P. S., S. Sucheta, V. S. Deepa, P. Selvamani and S. Latha. 2008. Antioxidative activity in some selected Indian medicinal plants. African Journal of Biotechnology. 7 (12): 1826-1828. |
| [48] | Kurnal, N. A. and S. C. C. Yalcin. 2009. Acaricidal, repellent and oviposition deterrent activities of Datura stramonium L. against adult Tetranychus utricae (Koch). J. Pest Sci. 14: 54-57. |
| [49] | Lounasmaa, M. and T. Taminnen. 1993. The tropane alkaloids, in the alkaloids. The alkaloids of academic press, New York. 44: 1-100. |
| [50] | Maibam, R. D., M. Bawari, S. B. Paul and G. D. Sharma. 2011. Neurotoxic and medicinal properties of Datura stramonium L. – Review. Assam university journal of science and technology biological and environmental sciences. 7: 139-144. |
| [51] | Mandal, B. K. and A. Shah. 2013. A review on pharmacological actions and use of plant Datura. Univer J Pharm. 2 (2): 47-51. |
| [52] | Mekonen, T., M. Giday, E. Kelbessa, 2015. Ethnobotanical study of home garden plants in Sabeta-Awas District of Oromia region in Ethiopia to assess use, species diversity and management practices. Journal of ethnobiology and ethnomedicine, 11 (64). |
| [53] | Muller, K. and H. A Arfmann. 1987. Investigation of alkaloid pattern of Datura stramonium plants by capillary gas-liquid chromatography mass-spestrometry. Planta Maedica. 53: 192-197. |
| [54] | Oudhia, P., R. S. Tripathi. 1998. Allelopathic potential of Datura stramonium L. Crop. Res. 16 (1): 37-40. |
| [55] | Oseni, O. A., C. O. Olarinoye and I. A. Amoo. 2011. Studies on chemical composition and functional properties of thorn apple. African Journal of Food Sciences. 5 (2): 40-44. |
| [56] | Philipov, S. and S. Berkov. 2002. GC-MS investigation of tropane alkaloids in Datura stramonium. Naturforsch C. 57: 559-561. |
| [57] | Parr, A. J., J. Payne, J. Eagles, B. T. Champan, R. T. Robins and M. J. Rhodes. 1990. Variation in tropane alkaloids accumulation within the Solanaceae and strategies for its exploitation. Phytochemistry. 29: 2545-2550. |
| [58] | Pawlowski, K., F. J. Kapeluszny, A. Kolasa and Z. Lycyk. 1967. Fertility of some species of ruderal weeds. Annales universitatis mariae curie-sklodowska lubin-polonia. 22 (15): 221-231. |
| [59] | Preissel U. Preissel, H. G. 2002. Brugmansia and datura: angel’s trumpets and thornapple. Buffalo NY: firefly books. pp: 106-129. |
| [60] | Protorius, E. and J. Marx. 2006. Datura stramonium in asthma treatment and possible effects on prenatal development. Environ. Toxicol Pharm. 21 (3): 331-337. |
| [61] | Puyvelde, V., L. I. Geysoen, F. X. Ayobangan, E. Hakizamungu and A. Nshimyimana, A. Kalisha. 1985. Science of medicinal plants of Ruanda for the acaricidal activity. Journal of Ethnopharmacology. 13: 209-215. |
| [62] | Rasekh, H. R., M. J. Khushnood-mansourkhani and M. Kamalinejad, M. Tariq, A. M Angel, J. S. Mossa and M. S Alsaid. 1989. Anti-inflammatory activity of Teucrium polium. International Journal on Tissue reaction. 11: 185-188. |
| [63] | Robins, R. G., A. G. Parr, J. Payne, N. J Walton and M. G. Rhodes. 1990. Factors regulating traopane alkaloids production in transformed culture of a Datura candida x Datura aurea hybrid. Planta. 181: 414-422. |
| [64] | Radford, A. E., H. E. Ahles and C. R. Bell. 1964. Mannual of vascular Flora of Carolinas. University of North Carolina press, Chapel Hill. 3 (5): 188-195 |
| [65] | Robins, R. J., A. J. Pars. E. C Bent and J. C. Rhodes. 1991. Studies on the biosynthesis of tropane alkaloids in Datura stramonium transformed root cultures. Planta. 183: 185-195. |
| [66] | Reddy, B. U. 2010. Enumeration of antibacterial activity of few medicinal plants by bioassay method. E. Journal of Chemistry. 7 (4): 1449-145. |
| [67] | Sazada, S., V. Arti, A. R. Ayaz, J. Faraha and K. Mukesh. 2009. Preliminary phytochemical analysis of some important medicinal and aromatic plants. 3 (5): 188-195. |
| [68] | Santh, R. T. 2006. Antibacterial activity of Adhatoda vasica leaf extracts. Asia j. Microbial. Biotech. |
| [69] | Salisbury, E. J. 1961. Weeds and Aliens. New naturalist series, Collins, London. |
| [70] | Sharma, M. C., S. Sharma. 2010. Phytochemical, preliminary pharmacognostical and antimicrobial activity of combined crude aqueous extracts. Int J. Microbial. Res. 1 (3): 166-170. |
| [71] | Sharma, N. and P. C. Trivedi. 2002. Screening of leaf extracts of some plants for their nematicidal and fungicidal properties against Meloidogyne incognita and Fusarium oxysporium. Asian journal of experimental sciences. 16: 21-28. Sharma, J., R. M. Painuli and R. D. Goruv. 2010. Plants used by rural communities of District Shahjahanpur, Uterpardesh. Indian Journal of Traditional Knowledge. 9: 798-803. |
| [72] | Shinwari, M. I. and M. A. Khan. 2000. Folk use of medicinal hills of Margalla Hills National park Islamabad. Journal of Ethnopharmacology. 69: 45-46. |
| [73] | Singh, S. K. K. Saroj, U. J. Tirupathi, A. K Singh and R. H. Singh. 1998. An antimicrobial principles from Spheranthus indicus. Int J crude drug. 26: 235-239. |
| [74] | Singh, H. B., R. S. Singh and I. S. Sandhu. 2003. Herbal medicines of Manipur. A colour encyclopedia, Daya publishing house Dehli. pp: 15. |
| [75] | Soni, P., A. A. Siddiqui, V. Soni. 2012. Pharmacological properties of Datura stramonium as a potential medicinal tree: An overview. Asian Pac. J. Trop. Biomed. 2: 1002-1008. |
| [76] | Srinivasan, Prashanth, and Smolke, Christina D. 2019. Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids. Nature Communications, 10 (1), 3634. doi: 10.1038/s41467-019-11588-w. |
| [77] | Stace, C. 1996. New flora of British Isles. Cambridge university press, Cambridge, UK, 2nd edition. Environ. Sci. 8 (2): 287-289. |
| [78] | Takhi, D., M. Ouinten. 2011. Study of antimicrobial activity of secondary metabolites extracted from spontaneous plants from the areas of Laghouat, Algeria. Adv. Environm. Biol. 5 (2): 469-476. |
| [79] | Taleb, A. 1995. Alore alustree des principales mauvaises des cultures du Gharb. pp: 294-295. |
| [80] | Theodore, C. B. Jasan, C. Dallus, B. Malanie, O. 2004. Jimson weed extract as a protective agentin severe organophosphate toxicity. Acad Emerg Med. 11 (4). pp: 335-338. |
| [81] | Toth, A., G. B. Benescsene and G. Balazs. 1997. Changes in field weeds in Hungary during the last 46 years. Proceedings of 1997 Brighton Conference – Weed. pp: 249-254. |
| [82] | Toth, A., G. Benesc-Bardi and G. Balazs. 1999. Results of National weed survey in arable land during past 50 years in Hungary. Proceedings of 1997 Brighton Conference – Weed. pp: 805-810. |
| [83] | Usha, K. B. Singh, P. Praseetha, N. Deepa, D. K. Agarwal, R. Agarwal, A. Nagaraja. 2009. Antifungal activity of Datura stramonium Calaotropis gigantea and Azadirachta indica against Fusarium magniferae and malformation in mango. European Journal of plant pathology. 124: 637-657. |
| [84] | Ventakesan, M., M. B. Vishwanathan and N. Ramesh. 2005. Antibacterial potential from Indian Suregada angustifolia. J. Ethnopharmacol. 99: 349-352. |
| [85] | Vitale, A. A. and A. Acher. 1995. Alkaloids of Datura ferox from Argentina. Journal of Ethnopharmacology. 49 (2): 81-89. |
| [86] | Weaver, S. E and S. I. Warwick. 1984. The biology of Canadian weeds. 64. Datura stramonium L. Canadian. |
| [87] | Waza, S. A. P. Anthony and S. Dar. 2015. Phytochemical analysis, antioxidant and antimicrobial activities of methanolic extracts of Datura stramonium seeds. IJPSR. 6 (7): 3021-3026. |
| [88] | Witt, A., Luke, Q., 2017. Guide to the naturalized and invasive plants of Eastern Africa, [ed. by Witt, A., Luke, Q.]. Wallingford, UK: CABI.vi + 601 pp. |
| [89] | Witte, Muller K and Arfmann HA, Investigation of the alkaloid pattern of Datura innoxia plants by capillary gas-liquid chromatography mass spectrometry, Planta Medica. 53; 1987: 192-197. |
| [90] | You. L. X. and S. J. Wang. 2011. Chemical composition and allelopathic potential of essential oil from Datura stramonium. Advanced Material Research. 2472-2475. |
APA Style
Aamana Batool, Zahra Batool, Rahmatullah Qureshi, Naveed Iqbal Raja. (2020). Phytochemicals, Pharmacological Properties and Biotechnological Aspects of Highly Medicinal Plant: Datura stramonium. Journal of Plant Sciences, 8(2), 29-40. https://doi.org/10.11648/j.jps.20200802.12
ACS Style
Aamana Batool; Zahra Batool; Rahmatullah Qureshi; Naveed Iqbal Raja. Phytochemicals, Pharmacological Properties and Biotechnological Aspects of Highly Medicinal Plant: Datura stramonium. J. Plant Sci. 2020, 8(2), 29-40. doi: 10.11648/j.jps.20200802.12
AMA Style
Aamana Batool, Zahra Batool, Rahmatullah Qureshi, Naveed Iqbal Raja. Phytochemicals, Pharmacological Properties and Biotechnological Aspects of Highly Medicinal Plant: Datura stramonium. J Plant Sci. 2020;8(2):29-40. doi: 10.11648/j.jps.20200802.12
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.jps.20200802.12,
author = {Aamana Batool and Zahra Batool and Rahmatullah Qureshi and Naveed Iqbal Raja},
title = {Phytochemicals, Pharmacological Properties and Biotechnological Aspects of Highly Medicinal Plant: Datura stramonium},
journal = {Journal of Plant Sciences},
volume = {8},
number = {2},
pages = {29-40},
doi = {10.11648/j.jps.20200802.12},
url = {https://doi.org/10.11648/j.jps.20200802.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.20200802.12},
abstract = {Plants are the backbone of the life on earth. They are essential resource for human well- being and among them Datura stramonium is one of highly important plants commonly known as Jimson weed. It is an annual herb found in temperate and sub-tropical areas. Its medicinal significance is mainly because of higher amounts of tropane alkaloids and traditionally used throughout the world. It possesses many phytoconstituents including alkaloids, flavonoids, amino acids, tannins, saponins, carbohydrates, terpenoids, steroidal glycosides and phenols. Various pharmacological activities i.e. anti-asthmatic, antimicrobial, antioxidant, anticancer and anti-inflammatory are exhibited by the plant. Secondary metabolites obtained from species of Datura genus produce tropane alkaloids which have influence on human nervous system and are used in medicines. Despite of its medicinal importance it is a potentially poisonous plant and known as plant hallucinogen. Its random use can cause restlessness and acute poisoning may lead to death. In global increasing energy demand scenario, Datura stramonium plant seeds oil is proved as an efficient source for biodiesel production. This paper will present an exclusive review with respect to the phytochemicals, ethno-medicinal, pharmacological and biotechnological aspects which will lay a solid foundation for further scientific research work to exploit the medicinal and industrial benefits of this plant.},
year = {2020}
}
TY - JOUR T1 - Phytochemicals, Pharmacological Properties and Biotechnological Aspects of Highly Medicinal Plant: Datura stramonium AU - Aamana Batool AU - Zahra Batool AU - Rahmatullah Qureshi AU - Naveed Iqbal Raja Y1 - 2020/04/28 PY - 2020 N1 - https://doi.org/10.11648/j.jps.20200802.12 DO - 10.11648/j.jps.20200802.12 T2 - Journal of Plant Sciences JF - Journal of Plant Sciences JO - Journal of Plant Sciences SP - 29 EP - 40 PB - Science Publishing Group SN - 2331-0731 UR - https://doi.org/10.11648/j.jps.20200802.12 AB - Plants are the backbone of the life on earth. They are essential resource for human well- being and among them Datura stramonium is one of highly important plants commonly known as Jimson weed. It is an annual herb found in temperate and sub-tropical areas. Its medicinal significance is mainly because of higher amounts of tropane alkaloids and traditionally used throughout the world. It possesses many phytoconstituents including alkaloids, flavonoids, amino acids, tannins, saponins, carbohydrates, terpenoids, steroidal glycosides and phenols. Various pharmacological activities i.e. anti-asthmatic, antimicrobial, antioxidant, anticancer and anti-inflammatory are exhibited by the plant. Secondary metabolites obtained from species of Datura genus produce tropane alkaloids which have influence on human nervous system and are used in medicines. Despite of its medicinal importance it is a potentially poisonous plant and known as plant hallucinogen. Its random use can cause restlessness and acute poisoning may lead to death. In global increasing energy demand scenario, Datura stramonium plant seeds oil is proved as an efficient source for biodiesel production. This paper will present an exclusive review with respect to the phytochemicals, ethno-medicinal, pharmacological and biotechnological aspects which will lay a solid foundation for further scientific research work to exploit the medicinal and industrial benefits of this plant. VL - 8 IS - 2 ER -
Email: