Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years

Mohammed Allam; Khaled Hamolila; Yahya Tikriti

doi:doi:10.11648/j.ajpn.20221002.13

| Peer-Reviewed

Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years

Mohammed Allam, Khaled Hamolila, Yahya Tikriti

Published in American Journal of Psychiatry and Neuroscience (Volume 10, Issue 2)

Received: 7 April 2022 Accepted: 9 May 2022 Published: 26 May 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

This is a case report of a 21 years old female patient with first episode psychosis fulfilling the DSM 5 criteria for paranoid schizophrenia with an interesting neuro-radiological finding found during the routine neuro-radiological screening of the first episode psychosis. The finding is of a large right lateral intraventricular thin walled cyst and signs of obstruction of the foramen of Monro. The objective of this paper is to present and review the different correlates of this case in light of the theories of etiology of the included disorders. Etiology of schizophrenia has different theories including the infectious theory with relevance to viral infections such as Herpes Simples Virus and Cytomegalovirus also non-viral infections such as Toxoplasmosis. Additional findings have also suggested that increased susceptibility to multiple pathogens in schizophrenic patients, rather than a specific agent, may play a role in the development of schizophrenia. The role of these infectious agents in the etiology of schizophrenia is proposed to be disrupting the neurodevelopment of the brain during critical phases of development in genetically predisposed individuals. On the other hand, the foramen of Monro becomes clinically significant when it is obstructed causing non communicating obstruction. Stenosis of the foramen of Monro has been attributed to infectious origins particularly the TORCH infections causing inflammation and scarring in the region (Toxoplasmosis, Other agents, Rubella, Cytomegalovirus and Herpes Simples). Etiologies of obstruction of the foramen of Monro also includes congenital atresia, vascular malformations, and neoplastic processes. There are different interesting views with regards to the significance of the neuro-radiological findings in the MRI of this case. Some of these views have bases related to clinical experience of directly managing similar cases with a documented outcome related to a specific intervention whether pharmacological or neurosurgical. Other views believe particular findings are incidental with no causal relationships with supporting references as below. In the same context we discussed the overlap between the two disorders in one theoretically possible etiology pertinent to the neurodevelopment theories of both disorders which is the infectious one.

Published in	American Journal of Psychiatry and Neuroscience (Volume 10, Issue 2)
DOI	10.11648/j.ajpn.20221002.13
Page(s)	77-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Fist Episode Psychosis, Early Onset Schizophrenia, Screening for First Episode Psychosis, Neurodevelopmental Theory of Schizophrenia, Arachnoid Brain Cyst

References

[1]	Fine. J. D. et al.; J Amer Acad Dermatol (April 1985; 12 (4)). Pp. 2477-78. The Torch Syndrome, A Clinical Review.
[2]	Geregory, E et al., Psychiatr Serv. 2017 May 01; 68 (5): 456–461. Incidence and presentation of first-episode psychosis in a population-based sample.
[3]	Early Psychosis Guidelines Writing Group and EPPIC National Support Program, Australian Clinical Guidelines for Early Psychosis, 2nd edition update, 2016, Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne.
[4]	Fatemi SH, Folsom TD (2009) The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull 35 (3): 528–548.
[5]	Andreasen NC (2010) The lifetime trajectory of schizophrenia and the concept of neurodevelopment. Dialogues Clin Neurosci 12 (3): 409–415.
[6]	Matthew M. Nour, and Oliver D. Howes. PNAS The Proceedings of the National Academy of Science, May 4, 2015 \| 112 (21) E2745. PNAS \| May 26, 2015 \| vol. 112 \| no. 21 \| E2745.
[7]	Chiapponi C, et al. (2013) Age-related brain trajectories in schizophrenia: A systematic review of structural MRI studies. Psychiatry Res 214 (2): 83–93.
[8]	Leishman’s Organic psychiatry – Text book – third edition. 2005.
[9]	Edinoff AN, et al. Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks. Neurol Int. 2022; 14 (1): 62-74. Published 2022 Jan 3.
[10]	Vijapurkar U et al., INVEGA SUSTENNA® [prescribing information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; January 2019.
[11]	Hough D, et al., Paliperidone palmitate maintenance treatment in delaying the time-to-relapse in patients with schizophrenia: a randomized, double-blind, placebo-controlled study. Schizophr Res. 2010, 116 (2-3): 107-117.
[12]	Ee Shern Liang et al., J Neurointerv Surg, 2021- Intracranial perianeurysmal cysts: case series and review of the literature.
[13]	G. A. Baquero, et al., The Open Neuroimaging Journal Vol.: 1–4.- 2014; 8, A schizophrenia-like psychotic disorder secondary to arachnoid cyst remitted with neurosurgical treatment of the cyst. The open neuroimaging journal.
[14]	Ceviker N, et-al. Neuroradiology. 1994; 36 (7): 519-2 Computed tomographic ventriculography: a clinicoradiological study of 31 cases.
[15]	Bartzokis G, et al. (2012) Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals. Biol Psychiatry 72 (12): 1026–1034.
[16]	Shane T, et al. Child’s nervous system. 2014; 30, 1645-1649.
[17]	Stranding S. Grays’ anatomy. Churchill Livingstone, (2005).
[18]	Priyanthi B, et al. Journal of neurodevelopmental disorders. volume 5, Article number: 21 (2013).

Cite This Article

Plain Text BibTeX RIS

APA Style

Mohammed Allam, Khaled Hamolila, Yahya Tikriti. (2022). Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years. American Journal of Psychiatry and Neuroscience, 10(2), 77-81. https://doi.org/10.11648/j.ajpn.20221002.13

Copy | Download

ACS Style

Mohammed Allam; Khaled Hamolila; Yahya Tikriti. Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years. Am. J. Psychiatry Neurosci. 2022, 10(2), 77-81. doi: 10.11648/j.ajpn.20221002.13

Copy | Download

AMA Style

Mohammed Allam, Khaled Hamolila, Yahya Tikriti. Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years. Am J Psychiatry Neurosci. 2022;10(2):77-81. doi: 10.11648/j.ajpn.20221002.13

Copy | Download

@article{10.11648/j.ajpn.20221002.13,
  author = {Mohammed Allam and Khaled Hamolila and Yahya Tikriti},
  title = {Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {10},
  number = {2},
  pages = {77-81},
  doi = {10.11648/j.ajpn.20221002.13},
  url = {https://doi.org/10.11648/j.ajpn.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221002.13},
  abstract = {This is a case report of a 21 years old female patient with first episode psychosis fulfilling the DSM 5 criteria for paranoid schizophrenia with an interesting neuro-radiological finding found during the routine neuro-radiological screening of the first episode psychosis. The finding is of a large right lateral intraventricular thin walled cyst and signs of obstruction of the foramen of Monro. The objective of this paper is to present and review the different correlates of this case in light of the theories of etiology of the included disorders. Etiology of schizophrenia has different theories including the infectious theory with relevance to viral infections such as Herpes Simples Virus and Cytomegalovirus also non-viral infections such as Toxoplasmosis. Additional findings have also suggested that increased susceptibility to multiple pathogens in schizophrenic patients, rather than a specific agent, may play a role in the development of schizophrenia. The role of these infectious agents in the etiology of schizophrenia is proposed to be disrupting the neurodevelopment of the brain during critical phases of development in genetically predisposed individuals. On the other hand, the foramen of Monro becomes clinically significant when it is obstructed causing non communicating obstruction. Stenosis of the foramen of Monro has been attributed to infectious origins particularly the TORCH infections causing inflammation and scarring in the region (Toxoplasmosis, Other agents, Rubella, Cytomegalovirus and Herpes Simples). Etiologies of obstruction of the foramen of Monro also includes congenital atresia, vascular malformations, and neoplastic processes. There are different interesting views with regards to the significance of the neuro-radiological findings in the MRI of this case. Some of these views have bases related to clinical experience of directly managing similar cases with a documented outcome related to a specific intervention whether pharmacological or neurosurgical. Other views believe particular findings are incidental with no causal relationships with supporting references as below. In the same context we discussed the overlap between the two disorders in one theoretically possible etiology pertinent to the neurodevelopment theories of both disorders which is the infectious one.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years
AU  - Mohammed Allam
AU  - Khaled Hamolila
AU  - Yahya Tikriti
Y1  - 2022/05/26
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpn.20221002.13
DO  - 10.11648/j.ajpn.20221002.13
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 77
EP  - 81
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20221002.13
AB  - This is a case report of a 21 years old female patient with first episode psychosis fulfilling the DSM 5 criteria for paranoid schizophrenia with an interesting neuro-radiological finding found during the routine neuro-radiological screening of the first episode psychosis. The finding is of a large right lateral intraventricular thin walled cyst and signs of obstruction of the foramen of Monro. The objective of this paper is to present and review the different correlates of this case in light of the theories of etiology of the included disorders. Etiology of schizophrenia has different theories including the infectious theory with relevance to viral infections such as Herpes Simples Virus and Cytomegalovirus also non-viral infections such as Toxoplasmosis. Additional findings have also suggested that increased susceptibility to multiple pathogens in schizophrenic patients, rather than a specific agent, may play a role in the development of schizophrenia. The role of these infectious agents in the etiology of schizophrenia is proposed to be disrupting the neurodevelopment of the brain during critical phases of development in genetically predisposed individuals. On the other hand, the foramen of Monro becomes clinically significant when it is obstructed causing non communicating obstruction. Stenosis of the foramen of Monro has been attributed to infectious origins particularly the TORCH infections causing inflammation and scarring in the region (Toxoplasmosis, Other agents, Rubella, Cytomegalovirus and Herpes Simples). Etiologies of obstruction of the foramen of Monro also includes congenital atresia, vascular malformations, and neoplastic processes. There are different interesting views with regards to the significance of the neuro-radiological findings in the MRI of this case. Some of these views have bases related to clinical experience of directly managing similar cases with a documented outcome related to a specific intervention whether pharmacological or neurosurgical. Other views believe particular findings are incidental with no causal relationships with supporting references as below. In the same context we discussed the overlap between the two disorders in one theoretically possible etiology pertinent to the neurodevelopment theories of both disorders which is the infectious one.
VL  - 10
IS  - 2
ER  -

Copy | Download

Author Information

Mohammed Allam

Adult Psychiatry Department, American Center for Psychiatry and Neurology (ACPN), Al Ain, United Arab Emirates
Khaled Hamolila

Adult Neurology Department, American Center for Psychiatry and Neurology (ACPN), Al Ain, United Arab Emirates
Yahya Tikriti

Adult Psychiatry Department, American Center for Psychiatry and Neurology (ACPN), Al Ain, United Arab Emirates

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Mohammed Allam, Khaled Hamolila, Yahya Tikriti. (2022). Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years. American Journal of Psychiatry and Neuroscience, 10(2), 77-81. https://doi.org/10.11648/j.ajpn.20221002.13

Copy | Download

ACS Style

Mohammed Allam; Khaled Hamolila; Yahya Tikriti. Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years. Am. J. Psychiatry Neurosci. 2022, 10(2), 77-81. doi: 10.11648/j.ajpn.20221002.13

Copy | Download

AMA Style

Mohammed Allam, Khaled Hamolila, Yahya Tikriti. Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years. Am J Psychiatry Neurosci. 2022;10(2):77-81. doi: 10.11648/j.ajpn.20221002.13

Copy | Download

@article{10.11648/j.ajpn.20221002.13,
  author = {Mohammed Allam and Khaled Hamolila and Yahya Tikriti},
  title = {Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {10},
  number = {2},
  pages = {77-81},
  doi = {10.11648/j.ajpn.20221002.13},
  url = {https://doi.org/10.11648/j.ajpn.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221002.13},
  abstract = {This is a case report of a 21 years old female patient with first episode psychosis fulfilling the DSM 5 criteria for paranoid schizophrenia with an interesting neuro-radiological finding found during the routine neuro-radiological screening of the first episode psychosis. The finding is of a large right lateral intraventricular thin walled cyst and signs of obstruction of the foramen of Monro. The objective of this paper is to present and review the different correlates of this case in light of the theories of etiology of the included disorders. Etiology of schizophrenia has different theories including the infectious theory with relevance to viral infections such as Herpes Simples Virus and Cytomegalovirus also non-viral infections such as Toxoplasmosis. Additional findings have also suggested that increased susceptibility to multiple pathogens in schizophrenic patients, rather than a specific agent, may play a role in the development of schizophrenia. The role of these infectious agents in the etiology of schizophrenia is proposed to be disrupting the neurodevelopment of the brain during critical phases of development in genetically predisposed individuals. On the other hand, the foramen of Monro becomes clinically significant when it is obstructed causing non communicating obstruction. Stenosis of the foramen of Monro has been attributed to infectious origins particularly the TORCH infections causing inflammation and scarring in the region (Toxoplasmosis, Other agents, Rubella, Cytomegalovirus and Herpes Simples). Etiologies of obstruction of the foramen of Monro also includes congenital atresia, vascular malformations, and neoplastic processes. There are different interesting views with regards to the significance of the neuro-radiological findings in the MRI of this case. Some of these views have bases related to clinical experience of directly managing similar cases with a documented outcome related to a specific intervention whether pharmacological or neurosurgical. Other views believe particular findings are incidental with no causal relationships with supporting references as below. In the same context we discussed the overlap between the two disorders in one theoretically possible etiology pertinent to the neurodevelopment theories of both disorders which is the infectious one.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years
AU  - Mohammed Allam
AU  - Khaled Hamolila
AU  - Yahya Tikriti
Y1  - 2022/05/26
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpn.20221002.13
DO  - 10.11648/j.ajpn.20221002.13
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 77
EP  - 81
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20221002.13
AB  - This is a case report of a 21 years old female patient with first episode psychosis fulfilling the DSM 5 criteria for paranoid schizophrenia with an interesting neuro-radiological finding found during the routine neuro-radiological screening of the first episode psychosis. The finding is of a large right lateral intraventricular thin walled cyst and signs of obstruction of the foramen of Monro. The objective of this paper is to present and review the different correlates of this case in light of the theories of etiology of the included disorders. Etiology of schizophrenia has different theories including the infectious theory with relevance to viral infections such as Herpes Simples Virus and Cytomegalovirus also non-viral infections such as Toxoplasmosis. Additional findings have also suggested that increased susceptibility to multiple pathogens in schizophrenic patients, rather than a specific agent, may play a role in the development of schizophrenia. The role of these infectious agents in the etiology of schizophrenia is proposed to be disrupting the neurodevelopment of the brain during critical phases of development in genetically predisposed individuals. On the other hand, the foramen of Monro becomes clinically significant when it is obstructed causing non communicating obstruction. Stenosis of the foramen of Monro has been attributed to infectious origins particularly the TORCH infections causing inflammation and scarring in the region (Toxoplasmosis, Other agents, Rubella, Cytomegalovirus and Herpes Simples). Etiologies of obstruction of the foramen of Monro also includes congenital atresia, vascular malformations, and neoplastic processes. There are different interesting views with regards to the significance of the neuro-radiological findings in the MRI of this case. Some of these views have bases related to clinical experience of directly managing similar cases with a documented outcome related to a specific intervention whether pharmacological or neurosurgical. Other views believe particular findings are incidental with no causal relationships with supporting references as below. In the same context we discussed the overlap between the two disorders in one theoretically possible etiology pertinent to the neurodevelopment theories of both disorders which is the infectious one.
VL  - 10
IS  - 2
ER  -

Copy | Download